List of most outscored college teams in history (through 10 games in a season) that currently play in the FBS:
Team PF - PA Difference
1916 SMU Mustangs 18 – 446 [428]
1993 Temple Owls 97 – 499 [402]
1981 Northwestern Wildcats 70 – 456 [386]
2005 Temple Owls 90 – 460 [370]
2008 Washington State Cougars 139 – 502 [363]
1950 Virginia Tech Hokies 72 – 430 [358]
2014 SMU Mustangs 97 – 441 [344]
1988 New Mexico Lobos 136 – 477 [341]
1973 UTEP Miners 142 – 481 [339]
1997 Louisiana Ragin Cajuns 152 – 490 [338]
This list was compiled from the information available at http://www.jhowell.net/cf/scores/byname.htm.
Two more 46 point losses, like this one, and the 2014 SMU team will have the record.